Naslov (eng)

Performance evaluation of the LC-MS/MS method for determination of chlorates in plant-origin foodstuffs

Autor

Stefanović, Srđan
Silađi, Čaba
Spirić, Danka
Petronijević, Radivoj
Bajčić, Aleksandar
Betić, Nikola
Jelušić, Vedrana

Publisher

Opis (eng)

Chlorate (ClO3-) is a monovalent inorganic anion obtained by deprotonation of chloric acid. Its widespread historic use (as an herbicide) and numerous present applications result in notable findings of chlorate residues in food commodities. The aim of this paper is to present validation data confirming the fitness for purpose of the modified “QuPPe” method for LC- MS/MS determination of chlorate in plant-origin foodstuffs with high water content. The validation study was conducted according to SANTE 11312/2021 in the form of a full initial validation on three matrices representative of the leafy vegetable group. The results of the key validation parameters demonstrate the fitness for purpose of the pro- posed method. Recovery values (96.5-105.3%), repeatability (4.1-16.2%), intermediate pre- cision (3.9-16.4%) and expanded measurement uncertainty (12.6-32.1%) are in compliance with the criteria laid down in the SANTE document. Use of a graphitized carbon column for the separation of chlorate introduces the necessary step of frequent preconditioning with pla- nar compounds e.g., chlorophyll. However, this process does not result in significant delays or extended run times if carried out regularly.

Jezik

engleski

Datum

2025-12-01

Licenca

Ovo delo je licencirano pod uslovima licence
Creative Commons CC BY 4.0 - Creative Commons Autorstvo 4.0 International License.

http://creativecommons.org/licenses/by/4.0/legalcode

Predmet

Chlorate, LC-MS/MS, Validation, SANTE, Hypercarb™

Deo kolekcije (1)

o:32

Institut za higijenu i tehnologiju mesa