Naslov (eng)

Cyclodextrin Applications: Towards Emerging Trends in Green Extractions of Bioactive Natural Compounds

Autor

Radan, Milica
Kuzmanović Nedeljković, Snežana
Živković, Jelena
Janković, Teodora
Lazarević, Zorica
Bigović, Dubravka
Šavikin, Katarina

Opis (eng)

In recent years, there has been an increasing demand for safer, cheaper, and more eco-friendly alternatives to toxic organic solvents. Cyclodextrin-based extractions represent an emerging “green” technology of great potential to enhance stability, solubility, and therefore bioavailability of poorly dissolved bioactive compounds. Polyphenolic compounds are receiving increasing attention due to their widespread distribution in plants and their numerous benefits to human health. The use of excipients, such as hydroxypropyl-β-cyclodextrin (HP-β-CD), in the production of polyphenolic-rich extracts from buckwheat herb (Fagopyrum esculentum Moench) could become a promising strategy for the extraction of target compounds. The application of mathematical and statistical methods, including response surface methodology (RSM) and artificial neural networks (ANN), in optimizing green extraction procedures represents an attractive approach for implementing environmentally responsible and sustainable extraction practices. By enabling a comprehensive influence analysis of each variable, the created and validated models allowed the estimation of the extraction parameters for the maximal recovery of bioactives and their further reliable predictions. Cyclodextrins showed not only positive impact on the extraction efficiency of polyphenolic compounds from buckwheat, but also on their stability after exposure to stress conditions. The unique conical cylinder shape of HP-β-CD facilitates the formation of inclusion complexes through host-guest interactions, including hydrogen bonding and hydrophobic interactions. The application of cyclodextrins in green extraction processes opens up new perspectives for more effective exploitation of natural plant resources and broader use in the food and pharmaceutical industries.

Jezik

engleski

Datum

2024

Licenca

© All rights reserved

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Radovi nastavnika i saradnika Instituta za proučavanje lekovitog bilja "Dr Josif Pančić"