Naslov (eng)

MICROENCAPSULATED ESSENTIAL OILS FROM TWO LAMIACEAE SPECIES FOR COMBAT AGAINST MULTI-RESISTANT ACINETOBACTER BAUMANNII

Autor

Kuzmanović Nedeljković, Snežana
Ćujić Nikolić, Nada
Stević, Tatjana
Bigović, Dubravka
Šavikin, Katarina
Filipić, Brankica

Opis (eng)

Antimicrobial resistance (AMR) threatens to increase its mortality rate to 10 million deaths per year by 2050, and Acinetobacter baumannii stands out with its insensitivity to almost all available therapeutic options. Potential solutions may be explored among naturally derived products, where essential oils (EOs) stand out with a broad spectrum of antimicrobial activity, complex chemical composition, and non-specific mechanisms of action postponing AMR development. Thus, we aimed to develop stable and effective microencapsulated systems of essential oils (EOs) derived from two species from Lamiaceae family, Origanum heracleoticum L. (oregano) and Thymus vulgaris L. (thyme). Microencapsulated complexes of oregano and thyme EOs (OEOC and TEOC) were prepared with hydroxypropyl-β-cyclodextrin as a carrier, and freeze-dried. The microdilution broth assay revealed higher antimicrobial activity of the OEOC sample compared to TEOC against 64 A. baumannii isolates recovered from COVID-19 patients admitted to intensive care units. Sub-inhibitory concentrations of microencapsulated EOs significantly decreased the biofilm formation of four A. baumannii isolates, representatives of a group of isolates based on the genetic pattern (Isolates 1, 2, 39, and 54). Contrary to antimicrobial potential, TEOC displayed slightly better antioxidant activity in the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay.

Jezik

engleski

Datum

2024

Licenca

© All rights reserved

Predmet

Acinetobacter baumannii, oregano essential oil, thyme essential oil

Deo kolekcije (1)

o:2594

Radovi nastavnika i saradnika Instituta za proučavanje lekovitog bilja "Dr Josif Pančić"