Naslov (eng)

Ten-year all-cause death following percutaneous or surgical revascularization in patients with prior cerebrovascular disease: insights from the SYNTAX Extended Survival study

Autor

Wang, Rutao
Takahashi, Kuniaki
Garg, Scot
Thuijs, Daniel J. F. M.
Kappetein, Arie Pieter
Mack, Michael J.
Morice, Marie‑Claude
Mohr, Friedrich‑Wilhelm
Curzen, Nick
Davierwala, Piroze
Milojević, Milan
Van Geuns, Robert Jan
Head, Stuart J.
Onuma, Yoshinobu
Holmes Jr., David R.
Serruys, Patrick W.

Opis (eng)

BACKGROUND: Coronary bypass artery grafting (CABG) has a higher procedural risk of stroke than percutaneous coronary intervention (PCI), but may ofer better long-term survival. The optimal revascularization strategy for patients with prior cerebrovascular disease (CEVD) remains unclear. METHODS AND RESULTS: The SYNTAXES study assessed the vital status out to 10 year of patients with three-vessel disease and/ or left main coronary artery disease enrolled in the SYNTAX trial. The relative efcacy of PCI vs. CABG in terms of 10 year all-cause death was assessed according to prior CEVD. The primary endpoint was 10 year all-cause death. The status of prior CEVD was available in 1791 (99.5%) patients, of whom 253 patients had prior CEVD. Patients with prior CEVD were older and had more comorbidities (medically treated diabetes, insulin-dependent diabetes, metabolic syndrome, peripheral vascular disease, chronic obstructive pulmonary disease, impaired renal function, and congestive heart failure), compared with those without prior CEVD. Prior CEVD was an independent predictor of 10 year all-cause death (adjusted HR: 1.35; 95% CI: 1.04–1.73; p=0.021). Patients with prior CEVD had a signifcantly higher risk of 10 year all-cause death (41.1 vs. 24.1%; HR: 1.92; 95% CI: 1.54–2.40; p<0.001). The risk of 10 year all-cause death was similar between patients receiving PCI or CABG irrespective of the presence of prior CEVD (p-interaction=0.624). CONCLUSION: Prior CEVD was associated with a signifIcantly increased risk of 10 year all-cause death which was similar in patients treated with PCI or CABG. These results do not support preferential referral for PCI rather than CABG in patients with prior CEVD. Trial registration: SYNTAX: ClinicalTrials.gov reference: NCT00114972. SYNTAX Extended Survival: ClinicalTrials. gov reference: NCT03417050.

Opis (eng)

Appendix: https://unilib.phaidrabg.rs/o:3465

Jezik

engleski

Datum

2020

Licenca

Ovo delo je licencirano pod uslovima licence
Creative Commons CC BY-SA 4.0 - Creative Commons Autorstvo - Deliti pod istim uslovima 4.0 International License.

http://creativecommons.org/licenses/by-sa/4.0/legalcode

Predmet

Key words: CABG, cerebrovascular disease, left main coronary artery disease, PCI, three-vessel disease

Deo kolekcije (1)

o:2793

Radovi saradnika Instituta za kardiovaskularne bolesti "Dedinje"