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Risk factors and incidence of deep venous thrombosis in non-severe coronavirus disease-19 patients
Babić, Srđan
Babić, Aleksandar
Stojičić, Milica
Genčić, Milena
Tanasković, Slobodan
Radoičić, Dragana
Gajin, Predrag
Atanasijević, Igor
Ilijevski, Nenad
BACKGROUND: The coronavirus disease (COVID-19) is characterized by a high prevalence of deep vein thrombosis (DVT), particularly in its severe form, but the incidence of DVT and risk factors for DVT in non-severe patients are still unknown. METHODS: The study enrolled 118 patients with non-severe COVID-19 infection which did not required hospital admittance. A duplex ultrasound and laboratory test were performed in all the patients after the first negative polymerase chain reaction SARS-CoV-2 test. RESULTS: DVT was identified in 50 (42.4%) patients with a median age of 48 years (interquartile range 30–85 years). Symptomatic DVT was present in 40 (80%) patients and was commonly seen in the Class I calf vein thrombosis (38 patients, 76%) (χ2 = 51.71, p < 0.001). The most significant risk factors for DVT were as follows: Increased C-reactive protein (p = 0.000), fibrinogen (p = 0.000), low lymphocyte count (p = 0.002), obesity (p = 0.017), and neutrophil count (p = 0.042). The multivariable logistic regression analysis revealed that a D-dimer cutoff point of 1253.5 µg/L showed a sensitivity of 92% and a specificity of 71%. CONCLUSION: Patients with increased inflammatory markers and obese patients after a non-severe COVID-19 infection should have an ultrasound examination to ensure early diagnosis of DVT and to prevent the occurrence of any complications.
engleski
2021
Ovo delo je licencirano pod uslovima licence
Creative Commons CC BY-NC 4.0 - Creative Commons Autorstvo - Nekomercijalno 4.0 International License.
http://creativecommons.org/licenses/by-nc/4.0/legalcode
Key words: coronavirus disease-19, D-dimer, deep vein thrombosis, doppler ultrasound scanning
10.3889/oamjms.2021.7455
126202889