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Dietary carbohydrates restriction inhibits the development of cardiac hypertrophy and heart failure
Nakamura, Michinari
Odanović, Natalija
Nakada, Yasuki
Dohi, Satomi
Zhai, Peiyong
Ivessa, Andreas
Yang, Zhi
Abdellatif, Maha
Sadoshima, Junichi
AIMS: A diet with modified components, such as a ketogenic low-carbohydrate (LC) diet, potentially extends longevity and healthspan. However, how an LC diet impacts on cardiac pathology during haemodynamic stress remains elusive. This study evaluated the effects of an LC diet high in either fat (Fat-LC) or protein (Pro-LC) in a mouse model of chronic hypertensive cardiac remodelling. METHODS AND RESULTS: Wild-type mice were subjected to transverse aortic constriction, followed by feeding with the Fat-LC, the Pro-LC, or a high-carbohydrate control diet. After 4 weeks, echocardiographic, haemodynamic, histological, and biochemical analyses were performed. LC diet consumption after pressure overload inhibited the development of pathological hypertrophy and systolic dysfunction compared to the control diet. An anti-hypertrophic serine/threonine kinase, GSK-3b, was re-activated by both LC diets; however, the Fat-LC, but not the Pro-LC, diet exerted cardioprotec-tion in GSK-3b cardiac-specific knockout mice. b-hydroxybutyrate, a major ketone body in mammals, was increased in the hearts of mice fed the Fat-LC, but not the Pro-LC, diet. In cardiomyocytes, ketone body supplementation inhibited phenylephrine-induced hypertrophy, in part by suppressing mTOR signalling. CONCLUSION: Strict carbohydrate restriction suppresses pathological cardiac growth and heart failure after pressure overload through distinct anti-hypertrophic mechanisms elicited by supplemented macronutrients.
Free full text at PMC https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8861266/
Appendix: https://unilib.phaidrabg.rs/o:3424
engleski
2021
Ovo delo je licencirano pod uslovima licence
Creative Commons CC BY-NC 4.0 - Creative Commons Autorstvo - Nekomercijalno 4.0 International License.
Podatak o licenci prema
https://v2.sherpa.ac.uk/id/publication/321
Key words: low-carbohydrate diet, cardiac hypertrophy, heart failure, ketone body
10.1093/cvr/cvaa298
125539081