Naslov (eng)

Preserving the bioactivity of elderflower through multifunctional microparticles

Autor

Mutavski, Zorana
Radan, Milica
Stasiłowicz-Krzemień, Anna
Mudrić, Jelena
Stević, Tatjana
Alimpić Aradski, Ana
Šavikin, Katarina
Cielecka-Piontek, Judyta
Ćujić Nikolić, Nada

Opis (eng)

Development of multifunctional natural bioactive systems with improved stability and biological activity is a key challenge in pharmaceutical and biomedical research. Sambucus nigra L. flowers are rich in polyphenols with antioxidant, antimicrobial, and antidiabetic properties; however, their application is limited by poor stability. Spray-drying microencapsulation represents an effective strategy to overcome this limitation. This study developed spray-dried elderflower extract microparticles using inulin and polydextrose as carriers, individually and in combination. The formulations were evaluated for antioxidant, antidiabetic (α-glucosidase and α-amylase inhibition), and antimicrobial activities. Microencapsulation successfully preserved biological activity. The free extract showed the highest antioxidant activity (DPPH IC50 0.27 mg/mL), while inulin-based formulations demonstrated improved α-glucosidase inhibition (IC50 3.66–3.74 mg/mL) compared to the non-encapsulated extract (IC50 4.18 mg/mL). Antimicrobial activity was also confirmed. Overall, the results indicate that inulin- and polydextrose-based microparticles represent promising multifunctional delivery systems for bioactive compounds with potential pharmaceutical applications.

Jezik

engleski

Datum

2026

Licenca

© All rights reserved

Predmet

bioactive stabilization, functional carriers, spray-drying systems

Deo kolekcije (1)

o:2594

Radovi nastavnika i saradnika Instituta za proučavanje lekovitog bilja "Dr Josif Pančić"